Description
Product Characteristics: Synonyms: DKFZp781A0122 antibody, Homologue to Drosophila photoreceptor protein calphotin antibody, KIAA0170 antibody, MDC 1 antibody, Mediation of DNA damage checkpoint 1 antibody
Target Information: The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008]