Description
Product Characteristics: RGS1, 1R20, regulator of G-protein signalling 1, BL34, IER1, IR20, 1R20, Regulator of G-protein signaling 1, B-cell activation protein BL34, early response protein 1R20, immediate-early response 1, B-cell specific
Target Information: This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]