Description
Product Characteristics: PKD2, polycystic kidney disease 2 (autosomal dominant), APKD2, MGC138466, MGC138468, PC2, PKD4, polycystin 2, polycystwin
Target Information: This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2. [provided by RefSeq, Mar 2011]