Description
Product Characteristics: ADAMTS8, ADAM metallopeptidase with thrombospondin type 1 motif, 8, ADAM-TS8, FLJ41712, METH2, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8
Target Information: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. [provided by RefSeq, Jul 2008]