Description
Product Characteristics: FITC anti-rat CD62L monoclonal antibody recognizes rat leukocyte selectin (L-selectin). CD62L is expressed constitutively on leukocytes and is expressed by a subset of thymocytes predominantly single positive CD4 or CD8 cells and a majority of lymph node cells in rats. CD62L binds well to O-glycans present on certain glycoforms of the mucins GlyCAM-1, CD34 and MAdCAM-1. CD62L is reported to be capable of reported to be capable of capable of transducing signals when cross-linked and has been shown to stimulate -integrin-mediated adhesion when bound to soluble GlyCAM-1. [1] L-selectin expressing CD4 CD8 thymocytes were shown through adoptive transfer to protect rats from insulin-dependent diabetes. CD4 CD8 thymocytes must mature to the stage of L-selectin expression before they can mediate normal T cell function. [2] Sensitive detection systems may be required on some tissues as expression of rat CD62L is weak.
Target Information: This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]