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Antibodies
Anti-Cleaved PARP1 antibody
Anti-Cleaved PARP1 antibody from Abcam
Be the first to write a review!
Citations:
(46)
Supplier Page
Supplier Page from
Abcam for
Anti-Cleaved PARP1 antibody
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
Anti-Cleaved PARP1 antibody
Company
Abcam
Price
Supplier Page
View Company Product Page
Catalog Number
ab4830
Antibody Type
Primary
Quantity
50 UL
Host
Rabbit
Applications
Immunocytochemistry, Western blot
Isotype
IgG
Clonality
Polyclonal
Conjugate/Tag
Unconjugated
Format
Purified from rabbit serum by sequential epitope-specific chromatography. The antibody has been negatively preadsorbed using a peptide spanning the cleavage site to remove antibody that is reactive with full length PARP. The final product is generated by affinity chromatography using a peptide corresponding to the PARP cleavage site
Research Area
Epigenetics
Gene Name
PARP1
Reactivity
Human, Recombinant fragment
Target
Cleaved PARP1
Add to Compare List
Abcam
Discovery Drive
Cambridge Biomedical Campus
Cambridge
CB2 0AX
United Kingdom
Phone
: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600
Company Profile
Website:
http://www.abcam.com
Citations (46)
(1)
Small molecule Z363 co-regulates TAF10 and MYC via the E3 ligase TRIP12 to suppress tumour growth
Clinical and translational medicine
January 1, 2023
Xiong Y, Wang L, Xu S, Fu B, Che Y, Zaky MY, Tian R, Yao R, Guo D, Sha Z,
et al
.
(
1:500
;
Santa Cruz
;
sc‐23900
), Cleaved‐Caspase 3 (
1:500
;
Abcam
;
ab2302
), Cleaced‐PARP1 (
1:1000
;
Abcam
;
ab4830
),
p53
(
1:500
;
Thermo Fisher Scientific
;
MA5‐12557
), Flag (
1:1000
; Beyotime; AF5051), HA (
1:1000
; Beyotime;
(2)
Ring finger protein 126 promotes breast cancer metastasis and serves as a potential target to improve the therapeutic sensitivity of ATR inhibitors
Breast Cancer Research
December 20, 2022
You Pan, Yuchao Yang, Rong Huang, Huawei Yang, Qinghua Huang, Yinan Ji, Jingxing Dai, Kun Qiao, Wei Tang, Longgui Xie,
et al.
(
AB265590
,
1:500
;
Abcam
); CDK2 (610,146,
1:200
; BD Biosciences); CDK5 (
AB40773
,
1:500
;
Abcam
); Cleaved PARP (
AB4830
,
1:200
;
Abcam
). After washing in Tris-buffered saline with 0.1% Tween 20 (TBST) for three times (10
(3)
A Pyrazolate Osmium(VI) Nitride Exhibits Anticancer Activity through Modulating Protein Homeostasis in HepG2 Cells
International Journal of Molecular Sciences
October 24, 2022
Chengyang Huang, Wanqiong Huang, Pengchao Ji, Fuling Song, Tao Liu, Meiyang Li, Hongzhi Guo, Yongliang Huang, Cuicui Yu, Chuanxian Wang,
et al.
(
CST
, 13E5, #
4970
), Cyclin B1 (
CST
, D5C10, #
12231
),
Caspase 3
(
CST
, D3R6Y, #
14220
), Cl-PARP1 (
Abcam
,
ab4830
), Cl-
caspase 3
(
Abcam
,
ab32042
),
Caspase 9
(
Abcam
,
ab202068
), and phospho-CDC2/CDK1 (R&D,Y15) were used
(4)
NAT10 and DDX21 Proteins Interact with RNase H1 and Affect the Performance of Phosphorothioate Oligonucleotides
Nucleic acid therapeutics
August 1, 2022
Zhang L, Bernardo KD, Vickers TA, Tian J, Liang XH, Crooke ST.
(
ab182156
),
NPM1
(
ab10530
),
NCL
(
ab134164
), acetylated alpha-tubulin (
ab24610
), and cleaved PARP1 (
ab4830
).
PSF
(
sc-374502
) and
P54
(
sc-376865
) antibodies were from
Santa Cruz Biotechnology
. The RNase H1 antibody
(5)
Carnosol Induces p38-Mediated ER Stress Response and Autophagy in Human Breast Cancer Cells
Frontiers in Oncology
May 31, 2022
Halima Alsamri, Aysha Alneyadi, Khalid Muhammad, Mohammed Akli Ayoub, Ali Eid, Rabah Iratni
Cell Signaling
(Beverly, MA, USA). Antibodies to phospho-IRE-1 (cat
Ab226974
) and cleaved PARP (cat.
Ab4830
) were obtained from
Abcam
(Cambridge, UK). Antibody to cleaved ATF6 (cat. A12570) was obtained from
(6)
LMO3 promotes proliferation and metastasis of papillary thyroid carcinoma cells by regulating LIMK1-mediated cofilin and the β-catenin pathway
Open Med (Wars)
March 7, 2022
Zeyi Ling, Xiaoli Long, Ying Wu, Jie Li, Mingliang Feng
and anti-β-actin (
ab8227
) (
1:3,000
;
Abcam
);
anti-cleaved caspase-3
(
ab2302
) and
anti-cleaved PARP
(
ab4830
) (
1:3,500
;
Abcam
); anti-cofilin (
ab42824
) and anti-p-cofilin (
ab12866
) (
1:4,000
;
Abcam
); anti-β-catenin
(7)
TRPA1 promotes cisplatin-induced nephrotoxicity through inflammation mediated by the MAPK/NF-κB signaling pathway
Annals of Translational Medicine
October 1, 2021
Jinyan Yuan, Xiao Liang, Wei Zhou, Jing Feng, Zhenyang Wang, Shaoxian Shen, Xin Guan, Liangbin Zhao, Fei Deng
anti-
TRPA1
,
Sigma
,
SAB1411593
,"
1:1,000
" Rabbit anti-PARP,
Abcam
,
ab74290
,"
1:1,000
" Rabbit
anti-cleaved-PARP
,
Abcam
,
ab4830
,"
1:1,000
" Rabbit anti-iNOS,
Abcam
,
ab178945
,"
1:1,000
" Rabbit anti-IKBα,Abcam,ab 7217,"
1:1,000
" Rabbit
(8)
Mutant p53L194F Harboring Luminal-A Breast Cancer Cells Are Refractory to Apoptosis and Cell Cycle Arrest in Response to MortaparibPlus, a Multimodal Small Molecule Inhibitor
Cancers (Basel)
June 18, 2021
Ahmed Elwakeel, Anissa Nofita Sari, Jaspreet Kaur Dhanjal, Hazna Noor Meidinna, Durai Sundar, Sunil C. Kaul, Renu Wadhwa
Technology (Danvers, MA, USA.);
anti-Poly ADP-Ribose polymer
[10H] (
ab14459
), and
anti-cleaved PARP1
(
ab4830
) from
Abcam
(Cambridge, UK). After washing with TBS-T, the blots were incubated for one hour with the
(9)
Role of Exendin-4 in Brain Insulin Resistance, Mitochondrial Function, and Neurite Outgrowth in Neurons under Palmitic Acid-Induced Oxidative Stress
Antioxidants (Basel, Switzerland)
January 9, 2021
Jo D, Yoon G, Song J.
#
3409
) (all from
Cell signaling
, Danvers, MA, USA). Cleaved-Poly (ADP-ribose) polymerase 1 (PARP-1,
ab4830
), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α,
ab54481
), and microtubule-associated
(10)
miR-152 Attenuates Apoptosis in Chondrocytes and Degeneration of Cartilages in Osteoarthritis Rats via TCF-4 Pathway
Dose-Response
October 27, 2020
Daqian Wan, Yang Qu, Songtao Ai, Liming Cheng
chemiluminescence
technique
. For the experiment the Iry antibodies used were
anti-cleaved PARP1
(
1:1000
) (
ab4830
),
anti–cleaved caspase 3
(
1:1000
) (
ab2302
), anti-
TCF4
(
1:1000
) (
ab185736
) from
Abcam
, USA. Anti-MMP-3
(11)
FGL1 regulates acquired resistance to Gefitinib by inhibiting apoptosis in non-small cell lung cancer
Respiratory research
August 10, 2020
Sun C, Gao W, Liu J, Cheng H, Hao J.
Cell Signaling Technology, USA), p-EGFR Y1173 (
ab5644
;
Abcam
), p-EGFR Y1068 (
ab5644
; Abcam), PARP1 (
ab4830
;
Abcam
), caspase 3 (
ab13847
;
Abcam
), and β-actin (
60008–1-Ig
;
Proteintech
, Wuhan, China). After
incubation
(12)
A small-molecule ARTS mimetic promotes apoptosis through degradation of both XIAP and Bcl-2
Cell death & disease
June 25, 2020
Mamriev D, Abbas R, Klingler FM, Kagan J, Kfir N, Donald A, Weidenfeld K, Sheppard DW, Barkan D, Larisch S.
cat#08691002) at a dilution of
1:50,000
. Cleaved PARP (cPARP)—rabbit polyclonal anti-PARP antibody (
Abcam
cat#
ab4830
) at a dilution of
1:1000
. Ubiquitin—
mouse
monoclonal anti-ubiquitin (
Santa Cruz
sc-8017
) at a dilution
(13)
FOXD3 may be a new cellular target biomarker as a hypermethylation gene in human ovarian cancer
Cancer Cell International
December 1, 2019
Gui-fang Luo, Chang-ye Chen, Juan Wang, Hai-yan Yue, Yong Tian, Ping Yang, Yu-kun Li, Yan Li
Actin antibody (
ab8227
,
Abcam
), anti-Annexin A2 antibody (
ab41803
,
Abcam
),
anti-Cleaved PARP1
antibody (
ab4830
,
Abcam
), anti-Casepase-3 antibody (
ab13847
,
Abcam
), and anti-GAPDH antibody (
ab9484
,
Abcam
). The graphs
(14)
Knockdown of Nedd8‑conjugating enzyme UBE2M suppresses the proliferation and induces the apoptosis of intrahepatic cholangiocarcinoma cells
Oncology Reports
September 20, 2019
Bin Zhao, Caiyan Gao, Daixiu Shi, Jie Mao, Jun Zhao, Lingyun Guo, Jiwu Guo, Zuoyi Jiao
poly (ADP‑ribose) polymerase (PARP;
1:1,000
; cat. no.
ab74290
;
Abcam
); cleaved (c)PARP (
1:1,000
; cat. no.
ab4830
;
Abcam
;
caspase‑3
(
1:1,000
; cat. no.
ab197202
;
Abcam
);
caspase‑9
(
1:1,000
; cat. no.
ab219590
;
Abcam
);
(15)
MiR-29b/Sp1/FUT4 axis modulates the malignancy of leukemia stem cells by regulating fucosylation via Wnt/β-catenin pathway in acute myeloid leukemia
Journal of experimental & clinical cancer research : CR
May 16, 2019
Liu B, Ma H, Liu Q, Xiao Y, Pan S, Zhou H, Jia L.
incubating with the primary antibody (FUT4,
AP12067b
,
Abgent
; cleaved caspase-3
ab2302
,
Abcam
; cleaved PARP,
ab4830
,
Abcam
; Sp1,
ab13370
,
Abcam
;
CD44
,
ab157107
,
Abcam
; GSK-3β, 22,104–1-AP, Proteintech; p-GSK-3β, 22,104–1-AP,
(16)
LncRNA MRAK048635_P1 is critical for vascular smooth muscle cell function and phenotypic switching in essential hypertension
Bioscience Reports
March 29, 2019
Genqiang Fang, Jia Qi, Liya Huang, Xianxian Zhao
(HC-101-02), anti-active caspase3 (
Abcam
,
ab2302
), anti-cleaved poly ADP-ribose polymerase (PARP) (
Abcam
,
ab4830
), anti-α-SMA (
Abcam
,
ab32575
), anti-SM22α (
Abcam
,
ab14106
), anti-Calponin (
Abcam
,
ab46794
), anti-Osteopontin
(17)
PARP inhibitor re‑sensitizes Adriamycin resistant leukemia cells through DNA damage and apoptosis
Molecular medicine reports
January 1, 2019
Wu J, Xiao S, Yuan M, Li Q, Xiao G, Wu W, Ouyang Y, Huang L, Yao C.
Biologicals, LLC, Littleton, CO, USA); caspase 3 (
1:1,000
; cat. no.
ab32351
), cleaved-PARP (
1:1,000
; cat. no.
ab4830
; both
Abcam
, Cambridge, UK); cyclinB1 (
1:1,000
; cat. no.
4138
); cleaved-caspase 3 (
1:2,000
; cat. no.
(18)
LINC01296/miR-26a/GALNT3 axis contributes to colorectal cancer progression by regulating O-glycosylated MUC1 via PI3K/AKT pathway
Journal of experimental & clinical cancer research : CR
December 14, 2018
Liu B, Pan S, Xiao Y, Liu Q, Xu J, Jia L.
Abcam
, the UK), cleaved caspase3 (
ab13585
,
Abcam
, the UK), PARP (
ab74290
,
Abcam
, the UK), cleaved PARP (
ab4830
,
Abcam
, the UK), MUC1 (
ab15481
,
Abcam
, the UK), PI3K-p110α (
21890–1-AP
,
Proteintech
, China), p-AKT 308
(19)
Bufalin suppresses hepatocarcinogenesis by targeting β-catenin/TCF signaling via cell cycle-related kinase
Scientific Reports
December 1, 2018
Zhuo Yu et al.
Cat#
ab49822
;
1:1000
), rabbit anti-
PARP
(
Abcam
, Cat#
ab227244
;
1:2000
), rabbit
anti-cleaved PARP
(
Abcam
, Cat#
ab4830
;
1:1000
), rabbit anti-CDC25A (cell signaling, Cat#ab3652;
1:1000
), rabbit anti-CDK6 (
Abcam
, Cat#
ab151247
;
(20)
PTEN inhibits non‑small cell lung cancer cell growth by promoting G0/G1 arrest and cell apoptosis
Oncology Letters
November 16, 2018
Libao Liu, Lei Huang, Jinyuan He, Songwang Cai, Yimin Weng, Shaohong Huang, Shaohong Ma
Cell Signaling Technology
, Inc. (Danvers, MA, USA). Rabbit polyclonal
anti‑cleaved PARP
antibody (cat. no.
ab4830
) was obtained from
Abcam
and
mouse
monoclonal anti‑ β ‑Actin antibody (cat. no.
sc‑47778
) was purchased
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Anti-Cleaved PARP1 antibody from Abcam
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