Description
Product Characteristics: FZD4, frizzled homolog 4 (Drosophila), CD344, EVR1, FEVR, FZD4S, Fz-4, FzE4, GPCR, MGC34390, WNT receptor frizzled-4, exudative vitreoretinopathy 1 (autosomal dominant, Criswick-Schepens syndrome), frizzled 4
Target Information: This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. [provided by RefSeq, Jul 2008]