MegaTOF™ Megadalton MALDI Mass Spectrometer from Shimadzu

Product Specs
ItemMegaTOF™ Megadalton MALDI Mass Spectrometer
CompanyShimadzu
Price Get Pricing Get Quote for this Product
Catalog NumberMegaTOF
QuantityEA
ApplicationsAntibody Characterization / Therapeutic Protein Aggregates / Inhibitors of Protein-Protein interactions / Protein Complexes Characterization / PEG Protein Characterization / High-Mass MALDI Imaging / Plasma Screening / Polymer Analysis
Ionization MethodMALDI
Mass AnalyzerTime-of-flight
Mass RangeUp to 2,000 kDa
Resolution180 at 200 kDa

Specifications/Features

Features:

High-sensitivity high-mass detector
Detects macromolecules up to 1,500 kDa
Conventional detector (electron multiplier)
Ideally suited for low mass (<10 kda)="">
15-second changeover time
Stabilization of molecule using crosslinking reagent kits

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Shimadzu

7102 Riverwood Drive

Columbia, Maryland

United States

Phone: 1-800-477-1227
1-800-477-1227
1-410-381-1222

Company Profile

Website: https://www.ssi.shimadzu.com/

(1) A Rapid Method for Direct Quantification of Antibody Binding-Site Concentration in SerumACS OmegaAugust 2, 2022Erwin G. Abucayon et al.(ThermoFisher) and bicinchoninic (BCA) assay. The molecular weight (MW) of mAb was established using the Axima MegaTOF (Shimadzu Scientific, MD). All ED experiments were done in rapid equilibrium dialysis (RED) plates with

(2) CaXyn30B from the solventogenic bacterium Clostridium acetobutylicum is a glucuronic acid-dependent endoxylanaseBMC Research NotesDecember 1, 2020Casey Crooks, Liangkun Long, Franz J. St Johnspotted on the MALDI-TOF plate and dried for analysis. Mass analysis was performed using a Shimadzu MegaTOF at the University of Wisconsin, Biochemistry Instrumentation Facility. Results In a recent publication

(3) Novel Vaccine That Blunts Fentanyl Effects and Sequesters Ultrapotent Fentanyl AnaloguesMolecular PharmaceuticsSeptember 8, 2020Rodell C. Barrientos, Eric W. Bow, Connor Whalen, Oscar B. Torres, Agnieszka Sulima, Zoltan Beck, Arthur E. Jacobson, Kenner C. Rice, Gary R. MatyasACN/H2O 0.1% formic acid (FA) and spotted on a MALDI-TOF 384-well stainless plate and loaded to the AXIMA MegaTOF instrument (Shimadzu Scientific Instruments, Columbia, MD). The instrument was calibrated using either

(4) Efficacy, but Not Antibody Titer or Affinity, of a Heroin Hapten Conjugate Vaccine Correlates with Increasing Hapten Densities on Tetanus Toxoid, but Not on CRM₁₉₇ CarriersBioconjugate ChemistryJune 17, 2015Rashmi Jalah et al.Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectroscopy (MALDI-TOF MS), using the Axima MegaTOF™ instrument (Shimadzu Scientific Instruments, Columbia, MD). Briefly, the unconjugated TT and CRM197

(5) Characterization and optimization of heroin hapten-BSA conjugates: method development for the synthesis of reproducible hapten-based vaccinesAnalytical and Bioanalytical ChemistrySeptember 1, 2014Oscar B. Torres, Rashmi Jalah, Kenner C. Rice, Fuying Li, Joshua F. G. Antoline, Malliga R. Iyer, Arthur E. Jacobson, Mohamed Nazim Boutaghou, Carl R. Alving, Gary R. Matyasthe coupling process. MALDI-TOF MS The mass of the MorHap-BSA conjugates was determined using Axima MegaTOF™ (Shimadzu Scientific Instruments, Columbia, MD). The Axima MegaTOF™ is capable of ultra high mass analysis

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