Among the aldehydes formed, 4-HNE is the major product of lipid peroxidation, and it has been suggested to play a major role in liver toxicity associated with lipid peroxidation. Prevents NF-κB activation and TNF expression by inhibiting IκB phosphorylation and subsequent proteolysis. (E)-4-Hydroxynonenal-dimethylacetal (Prod. No. ALX-270-375
) can be used for making a fresh preparation of HNE.