Chemical biology has been used successfully as both gain-of-function and loss-of-function approaches to study a variety of biological processes. For example, in chemical genetics, either small organic molecules or peptides are used to activate or inhibit specific proteins/enzymes involved in specific signal transduction pathways. This allows researchers to analyze the phenotype when a specific cellular protein is induced or suppressed.
EMD Millipore offers the Calbiochem® brand of high quality small molecules that have been cited in thousands of peer-reviewed publications. From libraries and pathway panels to individual small molecules, the Calbiochem® line of products offers the widest and most cited selection of inhibitors and activators worldwide.
Calbiochem® offers multiple small molecule libraries and panels:
• InhibitorSelect™ Libraries: collection of carefully selected, potent small molecules target members from several families of protein kinases and phosphatases to help reveal the signals regulating your phenotype of interest. Our inhibitor libraries offer the following advantages:
o Well characterized with strict quality control for reproducible results
o Structurally diverse compounds are useful to distinguish off-target effects
o High potency to yield unambiguous data
• StemSelect® Library: consists of 303 pharmacologically active, structurally diverse small molecules, including extracellular domain-targeting reagents as well as cell-permeable compounds that effectively regulate intracellular targets. The reagents in this library are useful for studying the survival, migration, proliferation, differentiation, signaling, and other functions of normal or cancer stem cells as well as non-stem cells.
• Signaling Pathway Panels: contain a collection of 12-16 carefully selected, cell permeable, and potent small molecules in convenient formats. These panels allow the researcher to zero in on their pathway of interest and gain useful information by manipulating specific proteins or families.