InSolution™ Tautomycetin, S. griseochromogenes from EMD Millipore

TC
TMC

Liquid. A 1 mM (50 µg/82 µl) solution (Cat. No. 580551) in DMSO. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable Tautomycin (Cat. No. 580551) structural analog that acts as a selective PP1 inhibitor with ~38-fold greater potency compared to PP2A (IC₅₀ = 1.6 nM for PP1 and 62 nM for PP2A). Inhibits LDP-1, PP2B, and PP5 only at much higher concentrations (IC₅₀ ≥ 1 µM). Shown to completely inhibit intracellular PP1 activity at 5 µM without affecting PP2A in COS-7 cells. TMC is superior to Cyclosporin A (Cat. No. 239835) as a T cell immunosuppressor both in vitro and in vivo. Purity: ≥95% by HPLC. RTECS WX0900000, CAS 119757-73-2, M.W. 606.7.