Biological safety cabinets should be decontaminated under the following conditions:
- Accessing the contaminated plenum, to change the filters, blowers, etc.
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Relocation of the cabinet from one room / building to another
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When the type of micro-organisms is drastically changed
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After a serious spill of a dangerous micro-organism
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When there is product contamination contributed to the cabinet
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Periodically, especially if BSL-3 or BSL-4 organisms are being manipulated inside the cabinet