20-hydroxy Leukotriene B4 from Cayman Chemical

20-hydroxy Leukotriene B4 from Cayman Chemical

Description

20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. 20-hydroxy LTB4 is not only much less active (~5%) compared to LTB4 in causing degranulation of PMNL, but actually inhibits LTB4-induced degranulation of human neutrophils (Ki = 13.3 nM). However, 20-hydroxy LTB4 is as active as LTB4 in contracting parenchymal strips from guinea pig lung. 20-hydroxy LTB4 retains considerable ligand binding affinity at the BLT2 receptor, but does not appear to function as an agonist

Specifications

Cayman Chemical
Cayman Chemical
Cayman Chemical Company 1180 East Ellsworth Road
Ann Arbor, Michigan 48108
United States
Phone: (800) 364-9897
(734) 971-3640

Citations