20-hydroxy Leukotriene B4 from Cayman Chemical

20-hydroxy Leukotriene B4 from Cayman Chemical

Description

20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. 20-hydroxy LTB4 is not only much less active (~5%) compared to LTB4 in causing degranulation of PMNL, but actually inhibits LTB4-induced degranulation of human neutrophils (Ki = 13.3 nM). However, 20-hydroxy LTB4 is as active as LTB4 in contracting parenchymal strips from guinea pig lung. 20-hydroxy LTB4 retains considerable ligand binding affinity at the BLT2 receptor, but does not appear to function as an agonist

Specifications

  • Detailed Specifications
  • Item20-hydroxy Leukotriene B4
  • CompanyCayman Chemical
  • Price Pricing InfoInquire
  • Catalog Number20190
  • Quantity.1 mg
  • Molecule Name20-hydroxy Leukotriene B4
Cayman Chemical
Cayman Chemical
Cayman Chemical Company 1180 East Ellsworth Road
Ann Arbor, Michigan 48108
United States
Phone: (800) 364-9897
(734) 971-3640

Citations