6α-Prostaglandin I1 from Cayman Chemical

6α-Prostaglandin I1 from Cayman Chemical

Description

6α-Prostaglandin I1 (6α-PGI1) is a stable Prostaglandin I2 (PGI2) analog resistant to hydrolysis in aqueous solutions. 6α-PGI1 promotes cyclic AMP accumulation in human thyroid slices and cells in a concentration dependent manner. However, it is about 10-fold less potent than the β-isomer and 100-fold less potent than PGI2 in eliciting the response. 6α-PGI1 exhibits an IC50 of 350 ng/ml for inhibition of ADP-induced platelet aggregation, which is nearly 900-fold higher than that observed for PGI2 (0.4 ng/ml)

Specifications

Cayman Chemical
Cayman Chemical
Cayman Chemical Company 1180 East Ellsworth Road
Ann Arbor, Michigan 48108
United States
Phone: (800) 364-9897
(734) 971-3640

Citations