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Products
Prostaglandin H2 & Analogs
U-46619
U-46619 from Cayman Chemical
Be the first to write a review!
Citations:
(21)
Supplier Page
Supplier Page from
Cayman Chemical for
U-46619
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Description
TXA2 receptor agonist; causes platelet shape change (EC50 ~6 nM) and aggregation (EC50 ~97 nM)
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
U-46619
Company
Cayman Chemical
Price
Pricing Info
Supplier Page
View Company Product Page
Catalog Number
16450
Quantity
1 mg
Research Area
Blood, Cardiovascular System, Coagulation & Hemostasis, Cyclooxygenase Pathway, Lipid Biochemistry, Smooth Muscle Cells, Vasculature
Format
A solution in methyl acetate
Molecular Weight
350.5
Purity
≥98%
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Cayman Chemical
Cayman Chemical Company 1180 East Ellsworth Road
Ann Arbor
,
Michigan
48108
United States
Phone
: (800) 364-9897
(734) 971-3640
Company Profile
Website:
http://www.caymanchem.com/
Citations (21)
(1)
An optimized protocol to isolate quiescent washed platelets from human whole blood and generate platelet releasate under clinical conditions
STAR Protocols
June 1, 2023
Luisa Weiss, Hayley MacLeod, Shane P. Comer, Sarah Cullivan, Paulina B. Szklanna, Fionnuala Ní Áinle, Barry Kevane, Patricia B. Maguire
recombinant proteins","Chemicals, peptides, and recombinant proteins" ,, U46619,
Cayman Chemical Company
,
16450
Thrombin
from bovine serum,
Sigma-Aldrich
,
T4648
MgCl2 × 6H2O,Sigma-Aldrich,M2393 NaCl,Sigma-Aldrich,S5886 NaHCO3,Sigma-Aldrich,S6014 Trizma
(2)
Retinopathy of prematurity protection conferred by uteroplacental insufficiency through erythropoietin signaling in an experimental Murine Model
Pediatric Research
April 4, 2023
Camille Fung, Thaonhi Cung, Caroline Nelson, Haibo Wang, Colin Bretz, Aniket Ramshekar, Ashley Brown, Gregory J. Stoddard, M. Elizabeth Hartnett
Cupertino, CA) containing either vehicle (0.5% ethanol) or 2000 ng/h of
U-46619
(TXA2 analog, catalog no.
16450
,
Cayman Chemical
, Ann Arbor, MI) were then placed into the retroperitoneum through a 1 cm incision.
(3)
High-Intensity Exercise Training Improves Basal Platelet Prostacyclin Sensitivity and Potentiates the Response to Dual Anti-Platelet Therapy in Postmenopausal Women
Biomolecules
October 17, 2022
Wickham KA, Nørregaard LB, Lundberg Slingsby MH, Cheung SS, Hellsten Y.
(0.08–80 µM;
A2754
,
Sigma-Aldrich
, St. Louis, MO, USA), and thromboxane A2 mimetic U46619 (0.02–40 µM;
16450
,
Cayman Chemical Company
, Ann Arbor, MI, USA). The 96-well half-area plate was covered with Parafilm
(4)
Epoxyeicosatrienoic Acid and Prostanoid Crosstalk at the Receptor and Intracellular Signaling Levels to Maintain Vascular Tone
International Journal of Molecular Sciences
May 25, 2022
Pedro Felipe Malacarne, Justus Bezzenberger, Melina Lopez, Timothy Warwick, Niklas Müller, Ralf P. Brandes, Flávia Rezende
USA).
11,12-EET
(#
50511
);
14,15-EET
(#
50651
);
14,15-EE-8(Z)-E
(#
10010486
); PGE2 (#
14010
); and U46619 (#
16450
) were from
Cayman Chemical
(MI, USA). 4.2. Animal
Procedure
Wild-type
mice
(C57Bl6J) were purchased
(5)
RhoBTB1 reverses established arterial stiffness in angiotensin II-induced hypertension by promoting actin depolymerization
JCI insight
May 9, 2022
Fang S, Wu J, Reho JJ, Lu KT, Brozoski DT, Kumar G, Werthman AM, Silva SD Jr, Muskus Veitia PC, Wackman KK,
et al
.
vasoconstriction response. For vasodilation responses, carotid artery rings were preconstricted with U46619 (
16450
,
Cayman Chemical
) to 40% to approximately 70% of maximum contraction, then treated with ACh (10–9 to
(6)
Assaying activity-dependent arteriole and capillary responses in brain slices
Neurophotonics
May 4, 2022
Danica Bojovic, Teresa L. Stackhouse, Anusha Mishra
handle with care. •
Agarose
(
Sigma-Aldrich
, cat. # A9793-50G)•
U-46619
(
Cayman Chemical Company
, cat. #
16450
)•
Dimethyl sulfoxide
(
Sigma-Aldrich
, cat. #
D8418
-250ML)•Isoflurane (anesthetic, e.g., Piramal
Critical Care
(7)
Constrictor responses of cerebral resistance arterioles in male and female rats exposed to prenatal alcohol
Physiological Reports
November 1, 2021
Partha S. Saha, Tiffany M. Knecht, Denise M. Arrick, Michael J. Watt, Jamie L. Scholl, William G. Mayhan
(1 and 10 µM) (Cat. No.
A9525
,
Sigma
), and the thromboxane analog
U‐46619
(10 and 100 nM) (Cat. No.
16450
,
Cayman Chemical
). Diameter of arterioles was measured before, and at 1‐minute intervals for 5 minutes
(8)
In vivo analysis of noise dependent activation of white blood cells and microvascular dysfunction in mice
MethodsX
October 8, 2021
Jonas Eckrich et al.
Roth GmbH + Co. KG, Karlsruhe, Germany)9,11-dideoxy-9α,11α-methanoepoxy
prostaglandin F2α
(
U-46619
,
16450
,
Cayman Chemical
, Ann Arbor, MI, USA)
Acetylcholine chloride
(A6625-25G,
Merck KGaA
, Darmstadt, Germany)Sodium
(9)
Interleukin-10 does not contribute to the anti-contractile nature of PVAT in health
Vascular Pharmacology
June 1, 2021
R.K. Kumar, L.M. Kaiser, C.E. Rockwell, S.W. Watts
following which a cumulative PE (10−8 to 10−4 M) or U46619 a thromboxane A2 agonist (10−10 to 10−5 M; #
16450
Cayman Chemical Company
, MI, USA) response curve was performed. PE and U46619 curves were performed
(10)
Homocysteine alters vasoreactivity of human internal mammary artery by affecting the K
Ca
channel family
Annals of translational medicine
April 1, 2021
Sun WT, Xue HM, Hou HT, Chen HX, Wang J, He GW, Yang Q.
increasing concentrations of the thromboxane A2 (TXA2) mimetic U46619 (−11–−4.5 LogM) (
Cayman Chemical
, Cat#
16450
) were added in the myograph chamber to generate a concentration-response curve. The role played by each
(11)
Intelligent classification of platelet aggregates by agonist type
eLife
May 12, 2020
Zhou Y, Yasumoto A, Lei C, Huang CJ, Kobayashi H, Wu Y, Yan S, Sun CW, Yatomi Y, Goda K.
salt BACHEM Cat#H-2936.0005
Platelet
activation Chemical compound, drug U46619
Cayman Chemical
Cat#
16450
Platelet
activation Chemical compound, drug 4% Paraformaldehyde
Phosphate Buffer
Solution WAKO Cat#30525-89-4 Fixation
(12)
Virtual optofluidic time-stretch quantitative phase imaging
APL Photonics
April 1, 2020
Haochen Yan, Yunzhao Wu, Yuqi Zhou, Muzhen Xu, Petra Paiè, Cheng Lei, Sheng Yan, Keisuke Goda
containing single
platelets
or with 50 μl of agonist solution contained 14-μM U46619 (
Cayman Chemical
,
16450
) for 10 min for the sample containing
platelet
aggregates. The sample was diluted using 5 ml of 0.9%
(13)
Prostaglandin E
2
and its receptor EP2 trigger signaling that contributes to YAP‐mediated cell competition
Genes to Cells
March 1, 2020
Erika Ishihara et al.
10–50 μM), ONO‐8711 (14070, 10 μM),
PF‐04418948
(
15016
, 10 μM), butaprost (
13740
, 10 μM),
U‐46619
(
16450
, 100 nM),
15(s)‐Fluprostenol
(
16787
, 10 μM), sulprostone (
14765
, 10 μM), BW245C (
12050
, 10 μM) and
Cicaprost
(14)
Neurovascular Coupling under Chronic Stress Is Modified by Altered GABAergic Interneuron Activity
The Journal of Neuroscience
December 11, 2019
Kayoung Han et al.
with ImageJ and Imaris software (Bitplane, RRID:SCR_007370). Pharmacological agents. U46619 (no.
16450
) was purchased from
Cayman Chemical
. TTX (
ab120055
) was purchased from
Abcam
.
NMDA
(
M3262
),
AMPA
hydrobromide
(15)
Illuminating G-Protein-Coupling Selectivity of GPCRs
Cell
June 13, 2019
Inoue A, Raimondi F, Kadji FMN, Singh G, Kishi T, Uwamizu A, Ono Y, Shinjo Y, Ishida S, Arang N,
et al
.
Institute,4014-v
Thrombin
,
Sigma-Aldrich
,
T4648
TIP39
,Peptide Institute,4479 s TUG 891,
Tocris Bioscience
,4601
U-46619
,
Cayman Chemical
,
16450
UDP,FUJIFILM Wako Pure Chemical,212–00861 UDP-Glucose,FUJIFILM Wako Pure Chemical,214–00941 Urotensin
(16)
Intrauterine Growth Restriction and Hyperoxia as a Cause of White Matter Injury
Developmental Neuroscience
November 14, 2018
Jill L. Chang, Mirrah Bashir, Christiana Santiago, Kathryn Farrow, Camille Fung, Ashley S. Brown, Robert W. Dettman, Maria L.V. Dizon
in the hip space. The pumps either contained the thromboxane A2 (TXA2)-analog
U-46619
(catalog no.
16450
,
Cayman Chemical
, Ann Arbor, MI, USA) dissolved in 0.5% ethanol or 0.5% ethanol (vehicle) which was
(17)
Platelet responses to pharmacological and physiological interventions in middle-aged men with different habitual physical activity levels
Acta Physiol (Oxf)
May 1, 2018
M. H. Lundberg Slingsby, L. Gliemann, M. Thrane, N. Rytter, J. Egelund, M. V. Chan, P. C. Armstrong, T. D. Warner, Y. Hellsten
20µM ADP (
A2754
Sigma
), 10µg/ml collagen (1130630, Takeda), 10µM of the TXA2 analogue U46619 Fo (
16450
,
Cayman Chemical Company
), 10µM thrombin receptor activating peptide (
TRAP-6
, SFLLRN H2936,
Bachem
),
(18)
Glial Cell Calcium Signaling Mediates Capillary Regulation of Blood Flow in the Retina
The Journal of neuroscience : the official journal of the Society for Neuroscience
September 7, 2016
Biesecker KR, Srienc AI, Shimoda AM, Agarwal A, Bergles DE, Kofuji P, Newman EA.
signaling. superfused with U46619, a thromboxane A2 receptor agonist, in ethanol (
Cayman Chemical
,
16450
; 200 nM for capillary experiments, 100 nM for Materials and Methods arteriole experiments) to generate
(19)
The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation
PLoS pathogens
August 1, 2016
Wang X, Shaw DK, Hammond HL, Sutterwala FS, Rayamajhi M, Shirey KA, Perkins DJ, Bonventre JV, Velayutham TS, Evans SM,
et al
.
Forskolin (
11018
),
Cytochalasin D
(
11330
), PGE2 (
14010
), PGD2 (
12010
) and U46619 (thromboxane A2 analogue,
16450
) were purchased from
Cayman
Chemicals. The PGE2 receptor antagonists EP1–1μM (SC51089), EP2–5μM (AH6809)
(20)
Thromboxane A2 modulates cisplatin-induced apoptosis through a Siva1-dependent mechanism
Cell death and differentiation
August 1, 2012
Iorio-Morin C, Germain P, Roy S, Génier S, Labrecque P, Parent JL.
(
cis-Diammineplatinum(II) dichloride
, cat.
P4394
) and cycloheximide (cat.
C4859
) were from
Sigma-Aldrich
. U46619 (cat.
16450
) and SQ29548 (cat.
19025
) were from
Cayman Chemical Company
. Plasmid constructs. The full-length open
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U-46619 from Cayman Chemical
Supplier Page
View Company Product Page
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