U-46619 from Cayman Chemical

Product Specs
ItemU-46619
CompanyCayman Chemical
Price Pricing Info Supplier Page View Company Product Page
Catalog Number16450
Quantity10 mg
Research AreaBlood, Cardiovascular System, Coagulation & Hemostasis, Cyclooxygenase Pathway, Lipid Biochemistry, Smooth Muscle Cells, Vasculature
FormatA solution in methyl acetate
Molecular Weight350.5
Purity≥98%

Add to Compare List

Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) An optimized protocol to isolate quiescent washed platelets from human whole blood and generate platelet releasate under clinical conditionsSTAR ProtocolsJune 1, 2023Luisa Weiss, Hayley MacLeod, Shane P. Comer, Sarah Cullivan, Paulina B. Szklanna, Fionnuala Ní Áinle, Barry Kevane, Patricia B. Maguirerecombinant proteins","Chemicals, peptides, and recombinant proteins" ,, U46619,Cayman Chemical Company,16450 Thrombin from bovine serum,Sigma-Aldrich,T4648 MgCl2 × 6H2O,Sigma-Aldrich,M2393 NaCl,Sigma-Aldrich,S5886 NaHCO3,Sigma-Aldrich,S6014 Trizma

(2) Retinopathy of prematurity protection conferred by uteroplacental insufficiency through erythropoietin signaling in an experimental Murine ModelPediatric ResearchApril 4, 2023Camille Fung, Thaonhi Cung, Caroline Nelson, Haibo Wang, Colin Bretz, Aniket Ramshekar, Ashley Brown, Gregory J. Stoddard, M. Elizabeth HartnettCupertino, CA) containing either vehicle (0.5% ethanol) or 2000 ng/h of U-46619 (TXA2 analog, catalog no. 16450, Cayman Chemical, Ann Arbor, MI) were then placed into the retroperitoneum through a 1 cm incision.

(3) High-Intensity Exercise Training Improves Basal Platelet Prostacyclin Sensitivity and Potentiates the Response to Dual Anti-Platelet Therapy in Postmenopausal WomenBiomoleculesOctober 17, 2022Wickham KA, Nørregaard LB, Lundberg Slingsby MH, Cheung SS, Hellsten Y.(0.08–80 µM; A2754, Sigma-Aldrich, St. Louis, MO, USA), and thromboxane A2 mimetic U46619 (0.02–40 µM; 16450, Cayman Chemical Company, Ann Arbor, MI, USA). The 96-well half-area plate was covered with Parafilm

(4) Epoxyeicosatrienoic Acid and Prostanoid Crosstalk at the Receptor and Intracellular Signaling Levels to Maintain Vascular ToneInternational Journal of Molecular SciencesMay 25, 2022Pedro Felipe Malacarne, Justus Bezzenberger, Melina Lopez, Timothy Warwick, Niklas Müller, Ralf P. Brandes, Flávia RezendeUSA). 11,12-EET (#50511); 14,15-EET (#50651); 14,15-EE-8(Z)-E (#10010486); PGE2 (#14010); and U46619 (#16450) were from Cayman Chemical (MI, USA). 4.2. Animal Procedure Wild-type mice (C57Bl6J) were purchased

(5) RhoBTB1 reverses established arterial stiffness in angiotensin II-induced hypertension by promoting actin depolymerizationJCI insightMay 9, 2022Fang S, Wu J, Reho JJ, Lu KT, Brozoski DT, Kumar G, Werthman AM, Silva SD Jr, Muskus Veitia PC, Wackman KK, et al.vasoconstriction response. For vasodilation responses, carotid artery rings were preconstricted with U46619 (16450, Cayman Chemical) to 40% to approximately 70% of maximum contraction, then treated with ACh (10–9 to

(6) Assaying activity-dependent arteriole and capillary responses in brain slicesNeurophotonicsMay 4, 2022Danica Bojovic, Teresa L. Stackhouse, Anusha Mishrahandle with care. •Agarose (Sigma-Aldrich, cat. # A9793-50G)•U-46619 (Cayman Chemical Company, cat. # 16450)•Dimethyl sulfoxide (Sigma-Aldrich, cat. # D8418-250ML)•Isoflurane (anesthetic, e.g., Piramal Critical Care

(7) Constrictor responses of cerebral resistance arterioles in male and female rats exposed to prenatal alcoholPhysiological ReportsNovember 1, 2021Partha S. Saha, Tiffany M. Knecht, Denise M. Arrick, Michael J. Watt, Jamie L. Scholl, William G. Mayhan(1 and 10 µM) (Cat. No. A9525, Sigma), and the thromboxane analog U‐46619 (10 and 100 nM) (Cat. No. 16450, Cayman Chemical). Diameter of arterioles was measured before, and at 1‐minute intervals for 5 minutes

(8) In vivo analysis of noise dependent activation of white blood cells and microvascular dysfunction in miceMethodsXOctober 8, 2021Jonas Eckrich et al.Roth GmbH + Co. KG, Karlsruhe, Germany)9,11-dideoxy-9α,11α-methanoepoxy prostaglandin F2α (U-46619, 16450, Cayman Chemical, Ann Arbor, MI, USA)Acetylcholine chloride (A6625-25G, Merck KGaA, Darmstadt, Germany)Sodium

(9) Interleukin-10 does not contribute to the anti-contractile nature of PVAT in healthVascular PharmacologyJune 1, 2021R.K. Kumar, L.M. Kaiser, C.E. Rockwell, S.W. Wattsfollowing which a cumulative PE (10−8 to 10−4 M) or U46619 a thromboxane A2 agonist (10−10 to 10−5 M; #16450 Cayman Chemical Company, MI, USA) response curve was performed. PE and U46619 curves were performed

(10) Homocysteine alters vasoreactivity of human internal mammary artery by affecting the K_Ca channel familyAnnals of translational medicineApril 1, 2021Sun WT, Xue HM, Hou HT, Chen HX, Wang J, He GW, Yang Q.increasing concentrations of the thromboxane A2 (TXA2) mimetic U46619 (−11–−4.5 LogM) (Cayman Chemical, Cat#16450) were added in the myograph chamber to generate a concentration-response curve. The role played by each

(11) Intelligent classification of platelet aggregates by agonist typeeLifeMay 12, 2020Zhou Y, Yasumoto A, Lei C, Huang CJ, Kobayashi H, Wu Y, Yan S, Sun CW, Yatomi Y, Goda K.salt BACHEM Cat#H-2936.0005 Platelet activation Chemical compound, drug U46619 Cayman Chemical Cat#16450 Platelet activation Chemical compound, drug 4% Paraformaldehyde Phosphate Buffer Solution WAKO Cat#30525-89-4 Fixation

(12) Virtual optofluidic time-stretch quantitative phase imagingAPL PhotonicsApril 1, 2020Haochen Yan, Yunzhao Wu, Yuqi Zhou, Muzhen Xu, Petra Paiè, Cheng Lei, Sheng Yan, Keisuke Godacontaining single platelets or with 50 μl of agonist solution contained 14-μM U46619 (Cayman Chemical, 16450) for 10 min for the sample containing platelet aggregates. The sample was diluted using 5 ml of 0.9%

(13) Prostaglandin E ₂ and its receptor EP2 trigger signaling that contributes to YAP‐mediated cell competitionGenes to CellsMarch 1, 2020Erika Ishihara et al.10–50 μM), ONO‐8711 (14070, 10 μM), PF‐04418948 (15016, 10 μM), butaprost (13740, 10 μM), U‐46619 (16450, 100 nM), 15(s)‐Fluprostenol (16787, 10 μM), sulprostone (14765, 10 μM), BW245C (12050, 10 μM) and Cicaprost

(14) Neurovascular Coupling under Chronic Stress Is Modified by Altered GABAergic Interneuron ActivityThe Journal of NeuroscienceDecember 11, 2019Kayoung Han et al.with ImageJ and Imaris software (Bitplane, RRID:SCR_007370). Pharmacological agents. U46619 (no. 16450) was purchased from Cayman Chemical. TTX (ab120055) was purchased from Abcam. NMDA (M3262), AMPA hydrobromide

(15) Illuminating G-Protein-Coupling Selectivity of GPCRsCellJune 13, 2019Inoue A, Raimondi F, Kadji FMN, Singh G, Kishi T, Uwamizu A, Ono Y, Shinjo Y, Ishida S, Arang N, et al.Institute,4014-v Thrombin,Sigma-Aldrich,T4648 TIP39,Peptide Institute,4479 s TUG 891,Tocris Bioscience,4601 U-46619,Cayman Chemical,16450 UDP,FUJIFILM Wako Pure Chemical,212–00861 UDP-Glucose,FUJIFILM Wako Pure Chemical,214–00941 Urotensin

(16) Intrauterine Growth Restriction and Hyperoxia as a Cause of White Matter InjuryDevelopmental NeuroscienceNovember 14, 2018Jill L. Chang, Mirrah Bashir, Christiana Santiago, Kathryn Farrow, Camille Fung, Ashley S. Brown, Robert W. Dettman, Maria L.V. Dizonin the hip space. The pumps either contained the thromboxane A2 (TXA2)-analog U-46619 (catalog no. 16450, Cayman Chemical, Ann Arbor, MI, USA) dissolved in 0.5% ethanol or 0.5% ethanol (vehicle) which was

(17) Platelet responses to pharmacological and physiological interventions in middle-aged men with different habitual physical activity levelsActa Physiol (Oxf)May 1, 2018M. H. Lundberg Slingsby, L. Gliemann, M. Thrane, N. Rytter, J. Egelund, M. V. Chan, P. C. Armstrong, T. D. Warner, Y. Hellsten20µM ADP (A2754 Sigma), 10µg/ml collagen (1130630, Takeda), 10µM of the TXA2 analogue U46619 Fo (16450, Cayman Chemical Company), 10µM thrombin receptor activating peptide (TRAP-6, SFLLRN H2936, Bachem),

(18) Glial Cell Calcium Signaling Mediates Capillary Regulation of Blood Flow in the RetinaThe Journal of neuroscience : the official journal of the Society for NeuroscienceSeptember 7, 2016Biesecker KR, Srienc AI, Shimoda AM, Agarwal A, Bergles DE, Kofuji P, Newman EA.signaling. superfused with U46619, a thromboxane A2 receptor agonist, in ethanol (Cayman Chemical, 16450; 200 nM for capillary experiments, 100 nM for Materials and Methods arteriole experiments) to generate

(19) The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome ActivationPLoS pathogensAugust 1, 2016Wang X, Shaw DK, Hammond HL, Sutterwala FS, Rayamajhi M, Shirey KA, Perkins DJ, Bonventre JV, Velayutham TS, Evans SM, et al.Forskolin (11018), Cytochalasin D (11330), PGE2 (14010), PGD2 (12010) and U46619 (thromboxane A2 analogue, 16450) were purchased from Cayman Chemicals. The PGE2 receptor antagonists EP1–1μM (SC51089), EP2–5μM (AH6809)

(20) Thromboxane A2 modulates cisplatin-induced apoptosis through a Siva1-dependent mechanismCell death and differentiationAugust 1, 2012Iorio-Morin C, Germain P, Roy S, Génier S, Labrecque P, Parent JL.(cis-Diammineplatinum(II) dichloride, cat. P4394) and cycloheximide (cat. C4859) were from Sigma-Aldrich. U46619 (cat. 16450) and SQ29548 (cat. 19025) were from Cayman Chemical Company. Plasmid constructs. The full-length open

Be the First to Write a Review!

U-46619 from Cayman Chemical

Description

Cayman Chemical

Citations (21)

Reviews

U-46619 from Cayman Chemical

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map